Trifexis Chewable Tablets for Dogs

Prescription Required
From $17.49


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All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped in the United States.
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Product Summary:

Prescription items are NON-RETURNABLE and NON REFUNDABLE

Trifexis® Chewable Tablets for Dogs

Trifexis is a monthly, chewable tablet for dogs that kills fleas, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis combines two trusted active ingredients to provide protection for your dog against these dangerous parasites. Trifexis starts working within 30 minutes from administration of this medicine to kill fleas and has been proven to kill all biting fleas within four hours. Trifexis also kills flea eggs before they can mature, which puts an end to the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms. Trifexis comes in a tasty beef-flavored tablet (made from pork liver and hydrolyzed soy) for ease of administration to your dog.

Item Specifications:

Trifexis is used to prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections.

For Use:
Dogs (at least 8 weeks of age and weighing at least 5 lb.)

Strength/Size: X-small (Pink) for dogs 5-10 lb.
Small (Orange) for dogs 10.1-20 lb.
Medium (Green) for dogs 20.1-40 lb.
Large (Blue_ for dogs 40.1-60 lb.
Xlarge (Brown) for dogs 60.1-120 lb.

Active Ingredient(s):
Spinosad, milbemycin oxime

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. This medication is generally well tolerated with other commonly prescribed medications. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together. Allergic reactions to medications may occur. Be sure to inform your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Side Effects:
Side effects may include nausea, vomiting, diarrhea, loss of appetite, decreased activity, itching, redness and inflammation of the skin. If you notice anything unusual, contact your veterinarian.

Trifexis should be given orally as directed veterinarian. Give Trifexis with food for maximum effectiveness.

Style Item Number Model Number UPC
40-60lbs 1 Month 497063 LG 1CT 012ELC-40-1-60-1
40-60lbs 6 Month 497063 LG 6CT 012ELC-40-1-60 309864335069
20-40lbs 1 Month 497063 MD 1CT 012ELC-20-1-40-1
20-40lbs 6 Month 497063 MD 6CT 012ELC-20-1-40 309864334062
10-20lbs 1 Month 497063 SM 1CT 012ELC-10-1-20-1
10-20lbs 6 Month 497063 SM 6CT 012ELC-10-1-20 309864333065
60-120lbs 1 Month 497063 XL 1CT 012ELC-60-1-120-1
60-120lbs 6 Month 497063 XL 6CT 012ELC-60-1-120 727804326777
5-10lbs 1 Month 497063 XS 1CT 012ELC-5-10-1
5-10lbs 6 Month 497063 XS 6CT 012ELC-5-10 727804322731
Additional Information:

Please Note: 

This prescription product or therapeutic food is fulfilled by Pet’s Choice Pharmacy, Inc. A licensed pharmacy in all states, excluding North Carolina. Pet’s Choice is working with North Carolina Board of Pharmacy to be licensed to fill prescriptions in the future. We can only ship to US states. 

To order prescription products or therapeutic foods must have an existing, valid veterinarian-client-patient relationship.  Prescription requests are subject to a Drug Utilization Review by a licensed pharmacist for patient safety.

All prescription products (excluding therapeutic food) are FDA approved, or EPA licensed, to be sold in the US. Prescription products cannot be returned.  


How do you fill my pet’s prescription order?

We understand how important your pet’s health is to you. That’s why we partnered with Pet’s Choice Pharmacy, a fully accredited Vet-VIPPS national pharmacy. Located in Belleville, Kansas, Pet’s Choice Pharmacy is a trusted partner that is fully licensed to distribute pharmaceutical products in all states, excluding North Carolina. This licensing ensures that they adhere to the proper standards for handling and dispensing pet medications directly to you, at a significant savings.


How does the prescription process happen?

Pet’s Choice Pharmacy will contact your veterinarian directly to obtain the necessary information and approval to dispense the medications ordered. It is helpful to have veterinarian’s name, phone number, and fax number when you place your order so we can speed up contact process with veterinarian. After prescription is verified, your medication will be safely dispensed and shipped directly to you. If you veterinarian does not participate or support online sales, you can mail your script to us directly.


Pet’s Choice Pharmacy  

814 K Street

Belleville, KS 66935 Order #


Are we a licensed pharmacy?

The National Association of Boards of Pharmacy (NABP) has approved us as an Internet Advertiser of prescription drug-related services through its e-Advertiser Approval program. We are not a licensed pharmacy; however, we are permitted to display pet medications on our site and have prescription orders fulfilled and delivered through our trusted partner, Pet’s Choice Pharmacy, a full Vet-VIPPS accredited pharmacy. This gives you a trusted and affordable alternative to purchase the medications your beloved pets need to maintain quality of life and overall health.


If you have any medical questions about your pet, we suggest you speak with your veterinarian before administering any medication.  If you would like to speak with our pharmacy support team about your order, you can contact us directly Monday-Friday 9 am-5 pm EST at (877) 574-2267. If you veterinarian needs to fax your prescription, our fax number is (866) 787-1177.


** By law we can only accept a prescription faxed from your veterinarian or we must have the original prescription**


Product Reviews by Customers

Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 6 questions Browse 6 questions and 28 answers
Why did you choose this? Store
Vet suggestion
Lynn R on Jun 13, 2019
Dr prescribed
Darryl T on Nov 19, 2018
Vet suggestion
Lynn R on Jun 13, 2019
Flea, tick, and heartworm medication that is well tolerated
Deb C on Jun 5, 2019
Dr prescribed
Darryl T on Nov 19, 2018
Both of my dogs have been on Trifexis for 5-7 years no issues I give them whole pill over series of 2 days by splitting it with no issues and have never seen a single flea on any of my dogs.
Robert T on Sep 30, 2018
My 12 yr old Toy Poodle has been on Trifexis her entire life. We have never had any issues.
Christie H on Aug 7, 2018
I have been using this product for (6) six years and have had no concerns. Both my dogs are healthy and have not had any flea or (tick) problems since.
Paul M on Jun 7, 2018
It works for my dog as preventive med for heartworm
Yolanda L on Apr 9, 2018
have used it before
Mike on Mar 22, 2018
I like the coverage it provides for my puppy
Taylor D on Jan 17, 2018
my vet no longer carriies and told me to order this online works good on my dog
Robin M on Jan 13, 2018
It has been the only thing that works in Alabama for complete flea and tick protection for my dogs
Michael M on Oct 22, 2017
vet recommendation
Mary Sue R on Oct 21, 2017
recommendation from vet
jeff c on Sep 24, 2017
It was suggested by our vet and our dogs do well on this product.
Twila L on Sep 23, 2017
convenient and cheaper.
Richie H on Aug 11, 2017
Happy with Trifexis as a Preventative
JANET T on Jul 27, 2017
it is all i have used and my dogs have never experienced any problems & have been very healthy.
Anthony T on Jun 13, 2017
Because it kills fleas and protects against infestation, prevents heartworm disease, and also treats and controls adult hookworms, roundworm and whipworm infestations. All of this in one chewable tablet. With some other medicines you have to buy 2 different medicines and it will cost a little more than Trifexis.
Jessica H on May 4, 2017
This is what my vet prescribe to help my dogs with fleas and protect against heart worms.
Karen H on Feb 3, 2017
A reliable and safe product that I trust to give my fur babies!
Kaitlin D on Mar 3, 2015
One pill once a month protects my dog from fleas, ticks and heartworm.
Michele M on Feb 10, 2015
Do used to take this and we started seeing fleas again
Jeffrey L on Dec 10, 2014
Flea, tick, and heartworm medication that is well tolerated
Deb C on Jun 5, 2019
Both of my dogs have been on Trifexis for 5-7 years no issues I give them whole pill over series of 2 days by splitting it with no issues and have never seen a single flea on any of my dogs.
Robert T on Sep 30, 2018
Is this product on the 25% off with $3.99 shipping?
spencer s on Jul 2, 2015
BEST ANSWER: Unfortunately , this item is not eligible for additional discounts.
Is there any way I can get 3 20-40lb tablets & 3 10-20lb tablets to complete a "6 month supply"?
Taylor N on Dec 3, 2014
BEST ANSWER: I'm sorry, this item is only sold in counts of 6.
Is this available in 3 months supply?
Jennifer C on Jan 2, 2017
BEST ANSWER: Not through this seller or as far as my quick Google search has revealed - it comes in a 6-pack .
Is this 6 months supply?
A shopper on Feb 14, 2019
BEST ANSWER: Yes, item is available in a 1 month or 6 month supply.
is this eligible for the 30$ off over $89?
A shopper on May 5, 2016
BEST ANSWER: No, prescription items are not eligible for promotional discounts.