K9 Advantix II for Dogs 6-Month Supply

List: $92.99
Today's savings: 27%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.10 lb.



Product Summary:

K9 Advantix II Dog: 6-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppie as young as 7 weeks old and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within 2 hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, and Anaplasmosis
  • Waterproof: continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes six applicators

Apply the entire contents of the tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell:

  • Imidacloprid: (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death
  • Permethrin: (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death
  • When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone
Downloadable Resources
Comparison ChartK9 Advantix II vs Frontline Plus
MSDSK9 Advantix II
Style Item Number Model Number UPC
4-10lb 405589 001 5420364 724089203649
11-20lb 405589 002 5420380 724089203809
21-55lb 405589 003 5420402 724089204028
Over 55lb 405589 004 5420429 724089204295

Product Reviews by Customers

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Browse 8 questions Browse 8 questions and 61 answers
Why did you choose this?
1800PetSupplies.com Store
Packaging and ease of application. Proven ingredients
Diana C on May 31, 2019
I have 6 dogs that need to be treated and its the best deal.
Anna P on Mar 1, 2019
Packaging and ease of application. Proven ingredients
Diana C on May 31, 2019
I have used the product before and feel confident it will work well for my pets
Carla R on Apr 5, 2019
I have 6 dogs that need to be treated and its the best deal.
Anna P on Mar 1, 2019
ratings its all in the ratings
Holly M on Jan 15, 2019
Debbie B on Oct 22, 2018
Works well to protect my baby girl.
Susan P on Sep 3, 2018
ticks are really bad, trying to keep them protected.
Crystal B on Aug 31, 2018
Heard this was good so giving it a try
virginia p on Jun 22, 2018
Excellent at keeping fleas and ticks away from my dog!
Trupti P on Jun 2, 2018
Won't have to buy as often.
William B on May 21, 2018
my new rescue is over 80 lbs and is 10 yrs old. i have been using this product for my other two dogs for a very long time with no problems.
marie d on May 14, 2018
This is a great product that works wonderfully for our dog. It's easy to apply. The price is affordable and its a safe product for our dog and our family. We are outdoors a lot with our dog and we don't want to have to worry about the fleas, ticks, mosquitos, etc.
Evan G on Apr 1, 2018
keep ticks off dogs
Victoria V on Mar 31, 2018
it really works
DEBRA C on Mar 11, 2018
Michelle S on Aug 8, 2017
This is the best price we have found.
Anthony F on Jun 3, 2017
always use this product seems to work
danny w on May 22, 2017
Best flea protection for my dogs
Jennifer R on May 13, 2017
I have two dogs.
Lareina B on May 8, 2017
Best to use in Texas on my Pets
Deborah H on May 5, 2017
price is fair, works well
Koren M on Apr 13, 2017
It works against both fleas and ticks!
amanda r on Mar 30, 2017
quality & price
Rudolph G on Mar 15, 2017
I chose this item because I have used it in the past and it works very well.
Kathy W on Mar 14, 2017
excellent product, easy to apply
Edith G on Mar 11, 2017
stocking up for flea season
Jennifer C on Mar 10, 2017
this product has worked well for my dog for many years
heidi b on Mar 10, 2017
great product.
mary s on Feb 19, 2017
It´s not only a good product. It´s also a product that have a good quality and it works.
Shelley S on Dec 22, 2016
I returned to using topical applications because the ticks here are very thick, and the expensive 8-month Seresto collar just doesn't do the job.
Layne A on Aug 17, 2016
Works the best
Linda R on Jul 26, 2016
used this for years with all 3 dogs never had a problem
Timothy K on Jul 3, 2016
my Vet recommend this product.
Harriett H on Jun 18, 2016
It works. I have used this brand for decades on multiple dogs and never had a flea or tick problem.
Jamie S on Jun 5, 2016
Have had no problems with fleas since using this product.
Susan R on May 17, 2016
Best rated flea and tick medicine for my pup.
Melanie S on May 16, 2016
Veterinary recommended, safe and it REPELS ticks, yippee!
Sandra H on Apr 20, 2016
went to the petco the price was a lot more
elva u on Apr 12, 2016
because as long we've used Advantage, which is over 15 years, we've never seen a flea on any of our pets.
Matt B on Apr 7, 2016
Used it last summer and never had a problem with flea or ticks.
Sheryl F on Mar 24, 2016
I found Frontline Plus to be less effective last year and I am hoping a switch up will help.
Trista G on Mar 22, 2016
it does a great job.
sharon d on Mar 19, 2016
The best option for the price.
Cheyenne M on Mar 9, 2016
Great Product
Jim S on Feb 28, 2016
I have used frontline before and it didn't seem to work on my dog. Frontline was a good product for cats.
Cathy B on Feb 21, 2016
I have read many GREAT reviews on this product and I am confident that it will be perfect for my pit bull.
Chayse M on Jan 28, 2016
hopefully a good price then in pet sores.
Nancy N on Dec 1, 2015
good deal
Robert M on Nov 19, 2015
this stuff works great .
joann c on Oct 22, 2015
LINDA Y on Oct 1, 2015
I have used the product before and feel confident it will work well for my pets
Carla R on Apr 5, 2019
ratings its all in the ratings
Holly M on Jan 15, 2019
Does k9 adv replaced heart worm treatments?
A shopper on Apr 7, 2018
BEST ANSWER: It’s a flea & tick preventative, NOT heartworm.
Does this also protect against heartworm?
A shopper on Aug 12, 2017
BEST ANSWER: Hi there,

No, this product does not protect against heartworms.
is this safe to use around cats?
A shopper on Mar 31, 2017
BEST ANSWER: Please allow the application to dry first and then it would not be harmful to the cat.
I have a dog that is 80 lbs and one that is 150 lbs do they each use one tube of the blue?
jo f on Apr 24, 2015
BEST ANSWER: The blue Advantix II is for dogs over 55 lbs so they both fall within the weight guidelines.
Does flea medicine expire, similar to people meds?
A shopper on Apr 19, 2015
BEST ANSWER: Kept unopened and sealed - this medicine does not expire.
can I use the 11-20 treatments for two maltese dogs under pounds?
A shopper on Apr 11, 2015
BEST ANSWER: The manufacturer instructions for use are to apply the entire contents of the tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail . This would suggest that you only use one tube per dog , following the weight guidelines.
Is adventix safe for use around small children?
A shopper on Feb 9, 2015
BEST ANSWER: As with any flea or tick preventative you must be careful handling it. Once it had dried on your dog it is safe but while wet i would avoid pet contact. I put mine on my dogs right before bed so that it has all night to dry before I have contact with my dog.