K9 Advantix II for Dogs 2-Month Supply

Regularly: $39.99
Today's savings: 28%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.50 lb.


Product Summary:

K9 Advantix II Dog: 2-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppies (as young as 7 weeks old) and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within two hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, Anaplasmosis
  • Waterproof; continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes 2 applicators

Apply entire contents of tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell.
Imidacloprid (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death.
Permethrin (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death.
When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone.

Downloadable Resources
Comparison ChartK9 Advantix II vs Frontline Plus
MSDSK9 Advantix II
Style Item Number Model Number UPC
4-10lb 405587 001 5406055 724089060556
11-20lb 405587 002 5406063 724089060631
21-55lb 405587 003 5406071 724089060716
Over 55lb 405587 004 5406098 724089060983

Product Reviews by Customers

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Browse 4 questions Browse 4 questions and 56 answers
Why did you choose this?
1800PetSupplies.com Store
Wife told me to.
John B on Feb 6, 2019
Wanted a good flea product.
Robin S on Aug 21, 2018
Wife told me to.
John B on Feb 6, 2019
because it seems cheaper.
Sandra H on Oct 3, 2018
Wanted a good flea product.
Robin S on Aug 21, 2018
rich E on Aug 5, 2018
i know it works, and price
Sheila F on Jun 25, 2018
Always had good luck using this product with my dog.
ANDREW M on Jun 6, 2018
Best on-line price!
Beverly V on Apr 21, 2018
I am giving this a try because the previous treatments I have used on my dogs require the tick, flea or mosquito to bite them. I don't want that as disease is transferred through saliva. I am hoping this keeps them from getting bit in the first place.
BECKY B on Mar 28, 2018
Effective. While I am reluctant to use chemicals on my dog, I continue to use Advantix as after 4 years of using this product, my dog has never had fleas.
Jeanette L on Mar 2, 2018
it has the same ingredient as some of the more expensive flea and tick control and it has a great price.
Tamara P on Nov 7, 2017
this product works the best for my Abbey and it is a very reasonable price
Christine C on Aug 10, 2017
value. Seems to work well
Sheila F on Jul 17, 2017
for the price
JAnne W on Jul 9, 2017
seemed like a good deal
MaryBeth S on May 25, 2017
Is the right time of the year
Gloria Aixa G on Apr 10, 2017
We've been using K9 Advantage to control fleas since it first came out with excellent results. We use Advantix if we're going to be in an area that also has ticks - again with excellent results.
Mary A G on Feb 18, 2017
We tried Frontline (it was on sale...bad owner!), poor pup was allergic. So, we are back to Advantix.
TABBY T on Aug 6, 2016
Heard nothing but great reviews on this. First time experience with my dog having fleas past the point of me being able to treat it.
Jordan S on Jun 4, 2016
cost was reasonable
stephen b on Jun 1, 2016
These item help prevent so many pests from our dogs.
maria c on Apr 20, 2016
This item takes care of fleas, ticks, and mosquitoes, all which are harmful to dogs, at a very reasonable price.
Elaine R on Apr 11, 2016
Used this product for several years. It always works
Michael W on Apr 4, 2016
i have used in thew past and it works.
Cynthia C on Nov 11, 2015
I have 3 golden retrievers...my babies....the other brands are not as good. This really works good on all of them. A great product!
Susan D on Nov 8, 2015
i have had great service in the past
Cindy B on Oct 23, 2015
Have used it for years, have 3 golden retrievers, has always worked, love this product.
Tammy S on Sep 18, 2015
This really works
SHERYL H on Sep 15, 2015
We have major tick problems here in Middle Tennessee, K9 Advantix II repels ticks and fleas in addition to killing them. Giving this product a test tryout to see if the dogs have any reaction to it; if not, we'll be back for more.
Becky B on Jul 24, 2015
Because I want full coverage for my fur children. fleas, ticks and mosquitos. It had a great review. Nothing but the best for my babies
sheryl k on Jul 5, 2015
Highly recommend by the vet for my 2 pug puppies
Sue L on Jun 14, 2015
I chose this because of it covers for the dogs. I used this last year also.
SANDY B on May 27, 2015
My sister-in-law told me to, and she is a vet.
Brian M on May 23, 2015
Advantix II works great for my dogs!
Shannon C on May 22, 2015
my vet recommended it...have used it befor
Jamie D on Apr 17, 2015
works well
Kelly M on Apr 15, 2015
Have used this before with success.
Kthleen F on Mar 24, 2015
It works very good, my dog has trouble with other like products, there is no problem with this product. It works fast and works like it is supposed to, also this site has better pricing than the others I looked at.
Denise D on Feb 6, 2015
picked these items because they were recomended by our vet
Lenaya J on Feb 4, 2015
it works well and the pricing isn't bad
Debra D on Jan 1, 2015
Highly recommended
vanessa d on Dec 3, 2014
I've used this product before and haven't found anything else that works as good. Very satisfied with K9 Advantix II. Used Frontline for years and the Advatix blows it away. Would highly reccommend.
Debby B on Nov 30, 2014
awesome product
DEBORAH R on Nov 24, 2014
It protects against mosquitoes. ..other brands claim they do, but don't. I've watched mosquitoes being repelled from my Pug and those that do bite die almost instantly. My pugs haven't had fleas or ticks since I've started using K9 Advantix II . It works. That's why I use it.
Jessica D on Nov 14, 2014
I use this all the time
Marjorie M on Nov 1, 2014
K9 is our go to. Frontline doesn't work on my dog anymore.
Cathy M on Oct 16, 2014
Great ratings.
Nadia H on Oct 4, 2014
i picked this item because it kills fleas and ticks. I have used this for 4 years now and never had problem with fleas or it hurting my furbabies i highly recommend this to anyone
wendy w on Sep 8, 2014
I have 2 puppies that are growing fast. I buy it month to month because I don't know what their weight will be next
KATIE B on Jun 18, 2014
Vet recommend this product. I was told this product work very well for my pet.
YVETTE G on Jun 9, 2014
best protection avail
Lorraine H on May 2, 2014
because it seems cheaper.
Sandra H on Oct 3, 2018
rich E on Aug 5, 2018
Hello, I at one time used a flea ad tick application that was in a tablet form and it was very effective since then I have used K9 Advantage and it was effective as well but wondered if you could telll me the ame of the tablet name ?
PAT M on Jul 23, 2017
BEST ANSWER: Hi there,

There are several oral flea/tick preventatives on the market. Some of these are prescription items and some are not. Some can also be given on a daily basis, whereas others last 4-12 weeks depending on the product.

If you visit our website and hover over "Dog" on the top left, a drop down will appear and you can sort products by flea/tick prevention. I hope this helps!
Is a prescription required for this product?
A shopper on Jun 23, 2016
BEST ANSWER: No, it does not require a prescription.
KIM on Apr 26, 2016
BEST ANSWER: The item listing states : Repels AND kills ticks, fleas, and mosquitoes .